The Joe Rogan Experience #2477 · March 31, 2026 · 2h 14m

#2477 - Rick Perry & W. Bryan Hubbard

Former Texas Governor Rick Perry and ibogaine advocate Bryan Hubbard make the case for ibogaine as a revolutionary treatment for opioid addiction. They claim it can reset the brain's dopamine and serotonin systems to pre-addiction levels in 36-48 hours with a single dose. Perry's unexpected pivot from conservative politics to psychedelic advocacy gives the conversation unusual political weight.

Novel

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Ibogaine: single-dose reset for opioid addiction

Ibogaine allegedly restores dopamine and serotonin to pre-opioid levels in 36-48 hours — 80% success first dose, 97% with a second.

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Highlights

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Rick Perry's journey from conservative governor to psychedelic advocate

A former Republican governor and Trump cabinet member now crusading for a Schedule I psychedelic — one of the more unlikely political transformations in recent memory.

Claude ChatGPT Gemini

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Ibogaine as the only known treatment for meth dependency

Perry and Hubbard claim ibogaine is the only substance that has shown effectiveness against methamphetamine addiction.

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Veterans as the proving ground for psychedelic therapy

Veterans with PTSD and addiction have become the primary population driving ibogaine advocacy, including Perry's personal conversion.

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Editorial

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Policy barriers to psychedelic medicine

Discussion of regulatory obstacles preventing ibogaine research and treatment in the US.

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Misc

✧Perry appeared on JRE previously (#2251) to discuss ibogaine — this is a return appearance

✧Americans for Ibogaine: americansforibogaine.org

✧Rogan has called ibogaine episodes 'some of the most important podcasts I've ever done'

✧BetterHelp sponsor — interesting juxtaposition with psychedelic therapy episode