No Priors
Hosted by Elad Gil & Sarah Guo
AI, technology, and startups with Elad Gil and Sarah Guo. Weekly interviews with the founders, researchers, and investors shaping the AI revolution. Both hosts are active AI investors with deep networks.
21 episodes processed
Host Profile
Two investor-hosts with deep technical knowledge. Sarah Guo brings VC pattern recognition, Elad Gil brings operator experience. 40-60 minutes. Focus on what's working now.
Episodes
Roblox CEO Dave Baszucki explores the intersection of AI, physics simulation, and the future of human connection on virtual platforms.
Laura Deming, CEO of Until, dives deep into reversible cryopreservation — the technology that could enable organ banking and eventually full-body preservation.
NVIDIA CEO Jensen Huang reflects on the biggest surprises of 2025, including rapid improvements in reasoning and the profitability of inference tokens.
Sarah and Elad forecast 2026: foundation model competition, expected IPOs from OpenAI and Anthropic, and the emerging robotics wave.
Sarah and Elad review their favorite conversations and biggest takeaways from 2025, identifying the trends that will define 2026.
Harvey co-founder Gabe Pereyra discusses why legal AI is about more than individual productivity — it is about putting together complex client matters to make law firms more profitable.
ElevenLabs co-founder Mati Staniszewski on how AI voice technology is transforming how humans interact with technology and each other.
Cheng Chi and Tony Zhao discuss the gap between impressive robot demos and real-world deployment, and what it takes to bridge that gap.
Stanford professor and World Labs founder Fei-Fei Li discusses spatial intelligence — AI that understands and reasons about the 3D physical world.
CAIS executive director Dan Hendrycks discusses the real risks of advanced AI: not science fiction scenarios but concrete near-term dangers from misuse, misalignment, and concentration of power.
OpenAI's Brandon McKinzie and Eric Mitchell discuss the development of o3 and how reasoning models represent a paradigm shift in AI capability.
Brendan Foody of Mercor discusses how AI is transforming talent matching and hiring, creating a new kind of labor market infrastructure.
Dr. Shiv Rao of Abridge discusses how AI medical scribes are transforming clinical documentation, freeing doctors to focus on patient care.
Palo Alto Networks CEO Nikesh Arora discusses how AI is both the biggest security threat and the most powerful security tool.
Zach Dell discusses patterns in enterprise AI adoption, identifying which categories of AI enterprise software are finding product-market fit.
Flagship Pioneering founder Noubar Afeyan discusses how AI is transforming drug discovery and biotech, and why the most impactful applications are not the most obvious ones.
OpenAI's Isa Fulford discusses developer experience, API design, and how OpenAI is building the platform environment for millions of AI developers.
Sarah Guo and Elad Gil review the year in AI, covering the biggest breakthroughs, surprises, and disappointments. They discuss the gap between AI hype and AI deployment, the emergence of AI agents, and their predictions for 2025.
NVIDIA CEO Jensen Huang discusses the architecture of AI infrastructure, why data center design is the new semiconductor design, and why he bet NVIDIA's future on AI computing a decade before ChatGPT proved him right.
Andrej Karpathy discusses his vision for autonomous intelligence -- AI systems that can learn, reason, and act independently. He covers the limitations of current LLMs, the path from tool AI to autonomous AI, and why the next breakthrough will come from systems that can write and execute their own code.
Scale AI founder Alexandr Wang discusses why data quality is the limiting factor in AI development, how Scale AI became the data backbone of every major AI lab, and why the next frontier of AI requires not just more data but fundamentally better data.