The Peter Attia Drive

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explores the topic of gray-market peptides, one of the most requested and most confusing topics he's covered on The Drive

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter takes a deep dive into the science and application of aging clocks, unpacking what they are, the differences between chronological age, biologica

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter answers listener questions across a wide range of topics, focusing on practical decision-making and real-world applicatio

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter takes a deep dive into obicetrapib, an investigational drug that has captured his attention and renewed interest in an entire class of th

Layne Norton dismantles the seed oil panic with actual data. Historical RCTs, LDL oxidation mechanisms, and why the dose makes the poison. Ultra-processed foods are the problem — not the type of oil in them.

Layne Norton PhD presents the evidence-based case that seed oils are not uniquely harmful under isocaloric conditions. Peter steelmans the strongest opposing arguments. Deep dive into LDL oxidation, historical RCTs, and scientific bias.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter brings together his most up-to-date thinking on cardiorespiratory fitness into a single, practical guide designed to help

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Abbie Smith-Ryan is a leading researcher in exercise physiology whose work focuses on how training and nutrition influence body composition, metabolism, cardiovascular

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter James Clear is the author of the New York Times bestseller Atomic Habits.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter presents a curated "best of" conversation with bestselling author and previous guest Arthur Brooks, organized around four co

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter tackles a wide-ranging set of listener questions spanning lifespan interventions, exercise, cardiovascular risk reduction

Dom D'Agostino on therapeutic ketosis for neurodegeneration and cancer. Ketones as an alternative brain fuel when glucose metabolism fails — the metabolic theory of Alzheimer's. Exogenous ketones, hyperbaric oxygen, and the military applications.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Carole Hooven is a human evolutionary biologist whose research centers on testosterone, sex differences, and behavior.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Walter Green is a remarkable philanthropist, mentor, author of This Is the Moment!, and founder of the impactful "Say It Now" movement.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Antonio Bianco is a world-renowned physician-scientist and expert in thyroid physiology and metabolism.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter breaks down the science of dietary fiber, moving beyond the blanket advice to "eat more fiber" to uncover what it actuall

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sally Greenwald is an OB-GYN who specializes in women's sexual health from a hormonal and physiologic perspective, with expertise spanning desire, arousal, pelvic floor

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter provides a comprehensive introduction to longevity, perfect for newcomers or those looking to refresh their knowledge.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter revisits the "proven, promising, fuzzy, noise, nonsense" scale and applies it to a variety of popular topics.

Rhonda Patrick on why the RDA for protein is dangerously low for anyone over 40. Anabolic resistance means older adults need MORE protein, not less. Creatine for both muscle and brain. Sauna as a longevity intervention with cardiovascular benefits rivaling exercise.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter David Allison is a world-renowned scientist and award-winning scientific writer who has spent more than two decades at the forefront of obesity research.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter addresses the recent headlines linking acetaminophen (Tylenol) use during pregnancy to autism in exposed children.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Joe Liemandt is a software entrepreneur turned education reformer who left Stanford in 1989 to found Trilogy, a highly profitable private software company, before pivot

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter hosts a strength and conditioning roundtable with three experts in the field—Gabrielle Lyon, Jeff Cavaliere, and Mike Boyle.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explores how to determine the right diet for yourself rather than searching for a universal "best" diet.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Edward Chang is a neurosurgeon, scientist, and a pioneering leader in functional neurosurgery and brain-computer interface technology, whose work spans the operating ro

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Stuart McGill is a distinguished professor emeritus at the University of Waterloo and the chief scientific officer at Backfitpro where he specializes in evaluating comp

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explains how to evaluate sugar and its substitutes in the context of health.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Charles Duhigg is a Pulitzer Prize-winning journalist and best-selling author known for distilling complex neuroscience and psychology into practical strategies for beh

Rhonda Patrick PhD on rethinking protein needs for performance and muscle preservation, plus the mental and physical benefits of creatine supplementation and sauna use.

Attia's evolved view on fasting: the metabolic benefits are real but the muscle loss is a serious trade-off for anyone over 40. His updated framework: time-restricted eating (10-12 hour window) is practical; extended fasts (3+ days) carry risks that may outweigh benefits for most people.

Tom Dayspring on why standard cholesterol testing is inadequate. ApoB — the number of atherogenic particles, not the cholesterol they carry — is the causal agent. Every additional year of elevated apoB accumulates irreversible arterial damage.

Three of the world's leading aging researchers debate: what works, what's hype, and what's coming. Rapamycin, senolytics, GLP-1 agonists, caloric restriction. The consensus: exercise remains the most proven geroprotective intervention. Everything else is promising but unproven in humans.

Arthur Brooks presents the science of happiness: why it declines in midlife, why achievement does not produce lasting satisfaction, and practical frameworks for building a happier life after the first mountain of career success.

Attia's foundational framework: Medicine 3.0 (proactive, not reactive). The four horsemen of death (CVD, cancer, neurodegeneration, metabolic disease). The 'centenarian decathlon' — training now for the physical tasks you want to perform at 90. Five pillars: exercise, nutrition, sleep, emotional health, drugs/supplements.

Peter Attia delivers a solo deep dive into Zone 2 cardiovascular training — the foundational exercise modality for longevity. Why 3-4 hours per week of Zone 2 is the single best exercise prescription for healthspan.

Dena Dubal on klotho — a longevity factor that protects cognitive function. Klotho levels decline with age and predict cognitive decline. A single injection of klotho improved cognition in aging mice. Exercise increases klotho; stress decreases it.

Paul Conti returns to discuss the relationship between emotional health and lifespan. The generative drive as the marker of health. How unprocessed trauma shortens life through chronic stress physiology. Self-audit strategies for emotional health.

Matthew Walker PhD returns for a comprehensive sleep masterclass covering the latest research on sleep stages, circadian biology, sleep aids, alcohol, and practical protocols for optimizing sleep quality.

Rhonda Patrick on the vascular hypothesis of Alzheimer's — how metabolic dysfunction (insulin resistance, inflammation) damages blood vessels that feed the brain, starving neurons decades before symptoms appear. Exercise and omega-3 supplementation as preventive interventions.

Attia's definitive exercise framework. Four pillars: Zone 2 cardio (mitochondrial health), Zone 5 intervals (VO2 max), strength training (sarcopenia prevention), stability (injury prevention). The hierarchy: stability > strength > Zone 2 > Zone 5.

San-Millán — coach to Tour de France winner Pogačar — on why Zone 2 is the most important training zone for both elite athletes and longevity seekers. Mitochondrial function, lactate clearance, fat oxidation, and metabolic flexibility.

Rick Johnson on why fructose is uniquely harmful — not because it's a sugar but because of HOW it's metabolized. Fructose triggers a 'survival switch' that promotes fat storage, insulin resistance, and uric acid elevation. The body even converts glucose to fructose when threatened.

Paul Conti's first appearance on The Drive. Trauma as an invisible epidemic — how unprocessed childhood experiences create shame cycles that drive addiction, relationship destruction, and chronic disease through persistent stress physiology.

Matthew Walker's landmark 3-part series on sleep. Sleep deprivation increases Alzheimer's risk, cardiovascular disease, cancer, and all-cause mortality. The glymphatic system clears beta-amyloid during deep sleep. Even one night of poor sleep measurably impairs immune function.