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TWIML

Hosted by Sam Charrington

The TWIML AI Podcast (formerly This Week in Machine Learning). Sam Charrington interviews leading ML researchers and practitioners. One of the longest-running and most respected AI research podcasts.

36 episodes processed

Host Profile

Themes
ML researchNLPcomputer visionroboticsAI infrastructuremodel evaluation
Style

Research-focused interviewer who goes deep on technical details. Charrington prepares extensively and asks informed follow-ups. 45-75 minutes. Conference coverage episodes.

Known Biases
Academic research emphasisMethodological rigorNeurIPS/ICML conference circuitBalanced industry/academia perspective
55 canon references

Episodes

# · Jan 29, 2026 · 55m
Yejin Choi

Yejin Choi discusses her research on making small language models reason more effectively, challenging the assumption that scale is the only path to intelligence.

2 canon
# · Jan 8, 2026 · 50m
Sam Charrington

Nikita Rudin discusses the gap between current robotic capabilities and what is required to deploy fully autonomous robots in the real world.

2 canon
# · Dec 17, 2025 · 55m
Sam Charrington

Aakanksha Chowdhery from Reflection explores the fundamental shifts required to build true agentic AI that can plan, act, and learn autonomously.

2 canon
# · Dec 9, 2025 · 55m
Sam Charrington

Munawar Hayat from Qualcomm AI Research discusses key papers from NeurIPS 2025, including advances in multimodal AI and solutions for object hallucination in vision-language models.

2 canon
# · Dec 2, 2025 · 50m
Sam Charrington

Zain Asgar from Gimlet Labs discusses running AI inference across heterogeneous hardware — mixing GPUs, CPUs, and custom accelerators for optimal performance.

2 canon
# · Nov 19, 2025 · 55m
Devi Parikh

Devi Parikh, co-founder of Yutori, discusses browser use models and how autonomous AI agents can navigate and act within web environments.

2 canon
# · Nov 12, 2025 · 50m
Sam Charrington

Robin Braun from HPE and Luke Norris from Kamiwaza discuss enterprise AI infrastructure challenges and how organizations can scale AI deployment effectively.

2 canon
# · Oct 15, 2025 · 55m
Sam Charrington

A deep dive into reasoning architectures: how chain-of-thought, tree-of-thought, and other inference-time compute strategies work and when to use each.

2 canon
# · Sep 10, 2025 · 50m
Sam Charrington

Advances in robotic manipulation: how AI systems learn to grasp, move, and manipulate objects in unstructured environments.

2 canon
# · Aug 5, 2025 · 55m
Sam Charrington

Research on LLM security: prompt injection attacks, jailbreaking techniques, data extraction, and emerging defense strategies.

2 canon
# · Jun 20, 2025 · 55m
Sam Charrington

Insights from training large foundation models: data curation, compute allocation, and the increasingly important role of data quality over data quantity.

2 canon
# · May 19, 2025 · 50m
Sam Charrington

Moving from responsible AI principles (fairness, transparency, accountability) to practical implementation — the organizational structures, evaluation pipelines, and cultural changes required to build AI responsibly.

2 canon
# · May 15, 2025 · 50m
Sam Charrington

How diffusion models are being applied beyond image generation: video, 3D modeling, protein design, and audio synthesis.

2 canon
# · Apr 10, 2025 · 48m
Sam Charrington

How organizations must rethink data governance for AI: new challenges around training data provenance, model outputs, and the blurred line between data and code.

2 canon
# · Mar 24, 2025 · 52m
Cristobal Valenzuela

Runway CEO Cristobal Valenzuela discusses whether video generation represents a path toward artificial general intelligence — the argument that world models trained on video data must develop physical reasoning.

1 canon
# · Mar 15, 2025 · 55m
Sam Charrington

The state of reinforcement learning: from game-playing to robotics to RLHF. How RL has evolved from a research curiosity to a core component of modern AI systems.

2 canon
# · Feb 10, 2025 · 50m
Sam Charrington

Bridging the gap between AI ethics theory and practice. How organizations can move from principled statements to concrete implementation of ethical AI.

2 canon
# · Feb 10, 2025 · 48m
Sam Charrington

The emerging field of edge AI deployment — running machine learning models on devices (phones, cameras, sensors) rather than in the cloud. The challenges of model compression, latency, and power efficiency.

1 canon
# · Jan 22, 2025 · 50m
Sam Charrington

Alexandre Pesant from Lovable discusses the evolution and practice of vibe coding — building software through natural language descriptions rather than manual code.

2 canon
# · Dec 17, 2024 · 55m
Mike Cannon-Brookes

Atlassian co-CEO Mike Cannon-Brookes shares internal data on AI tool adoption across 300,000+ enterprise customers — what AI features are actually used, which are ignored, and what this reveals about enterprise AI readiness.

1 canon
# · Nov 18, 2024 · 55m
Sam Charrington

A clinical informatics researcher separates the hype from reality in healthcare AI: which applications are actually deployed in clinical settings, which remain research demonstrations, and why the gap exists.

1 canon
# · Oct 14, 2024 · 52m
Sam Charrington

A critical examination of AI safety evaluation methodologies: red-teaming, benchmarks, and stress testing — what they actually measure, what they miss, and why the field lacks agreed-upon standards.

1 canon
# · Sep 16, 2024 · 50m
Arvind Jain

Arvind Jain, CEO of Glean, discusses the evolution from enterprise search to agentic AI tools for the workplace — how Glean went from finding documents to acting on them.

1 canon
# · Aug 5, 2024 · 50m
Sam Charrington

The convergence of vision, language, and audio in multimodal generative AI systems — how models that can see, speak, and write simultaneously are creating new capabilities and new challenges.

1 canon
# · Jul 22, 2024 · 55m
Thomas Dohmke

GitHub CEO Thomas Dohmke discusses how AI is transforming software engineering through Copilot and beyond — the shift from AI as autocomplete to AI as a development partner.

2 canon
# · Jun 17, 2024 · 55m
Sam Charrington

How AI is transforming scientific discovery beyond the headline achievements of AlphaFold — applications in materials science, drug discovery, climate modeling, and mathematics.

1 canon
# · May 20, 2024 · 48m
Sam Charrington

A deep dive into synthetic data: how AI-generated training data is replacing real data in many applications, the quality challenges, and the risk of model collapse when models are trained on outputs of other models.

1 canon
# · Apr 8, 2024 · 50m
Sam Charrington

Christopher Manning from Stanford discusses the intersection of linguistics and large language models — whether LLMs truly understand language or process it as statistical patterns, and what this distinction means for the field.

1 canon
#675 · Mar 11, 2024 · 55m
Sam Charrington

A nuanced discussion of the risks and benefits of releasing open-weight AI models, challenging both the AI safety maximalist view (all models should be closed) and the open-source maximalist view (all models should be open).

1 canon
#674 · Mar 4, 2024 · 50m
Sam Charrington

The AI2 team discusses OLMo, their fully open-source large language model that releases not just weights but training data, training code, and evaluation frameworks — everything needed to reproduce and study the model.

1 canon
#673 · Feb 26, 2024 · 48m
Sam Charrington

An exploration of how training data composition affects chain-of-thought reasoning capabilities in LLMs, and whether prompting techniques actually elicit genuine reasoning or sophisticated pattern matching.

1 canon
#672 · Feb 19, 2024 · 50m
Sam Charrington

JPMorgan AI Research discusses DocLLM, their approach to reasoning over complex business documents that combine text, tables, and figures — a fundamental challenge for enterprise AI deployment.

1 canon
#671 · Feb 12, 2024 · 52m
Sam Charrington

A critical examination of whether emergent abilities in large language models are genuine phase transitions or measurement artifacts caused by nonlinear evaluation metrics.

1 canon
#670 · Feb 5, 2024 · 55m
Sam Charrington

Kamyar Azizzadenesheli from NVIDIA discusses how the reinforcement learning community is adapting to the dominance of large language models — where RL techniques enhance LLMs and where LLMs change RL.

1 canon
#665 · Jan 15, 2024 · 52m
Sam Charrington

Naila Murray discusses 2024 trends in computer vision: the integration of vision with language models, the challenge of 3D understanding, and how video generation is reshaping the field.

1 canon
#664 · Jan 8, 2024 · 55m
Thomas Dietterich

Thomas Dietterich discusses 2024 AI trends in machine learning and deep learning, including the tension between monolithic LLMs and modular architectures, hallucination challenges, and the role of uncertainty quantification.

2 canon