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The Tim Ferriss Show #845 · January 6, 2026 · 2h 22m
How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino
Dr. Dominic D'Agostino on ketosis — mood, cognition, brain protection, metabolic psychiatry. GABA elevation reduces neural excitability; Alzheimer's prevention through metabolic health. Mix of tactical dietary content and research-backed cognitive findings.
Curious
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2025 JAMA Psychiatry meta-analysis: ketogenic diets show small-to-medium effect on depression. GABA elevation reduces neural excitability.
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Brain insulin resistance as Alzheimer's pathway. 144-study meta-analysis supports the link. Ketones as alternative fuel.
Editorial
Misc
✧D'Agostino is also a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition
✧This is his 4th or 5th appearance on the Ferriss show — D'Agostino is a recurring guest
✧Tim's own keto experiment deconstructed in this episode
✧Metabolic psychiatry is an emerging field — treating mental health through metabolism